How Long Does Ketamine Relief Last?
- Adam O'Neill
- May 6
- 2 min read
Ketamine therapy is making headlines for its fast-acting and transformative effects on treatment-resistant depression, anxiety, PTSD, and chronic pain. But one of the most common questions we hear at Mosaic Infusions & Wellness is: “How long does ketamine relief actually last?”
The answer depends on a few key factors—including your condition, treatment plan, and how your body responds. Let’s break down what to expect from the timeline of results after ketamine infusions.
How Quickly Does Ketamine Work?
One of the most remarkable aspects of ketamine is how quickly it can begin to relieve symptoms—often within hours or days of the first treatment.
Research Highlights:
A 2021 review published in The American Journal of Psychiatry found that up to 70% of patients with treatment-resistant depression experienced significant improvement after just one to two infusions.
Relief is often noticeable within 4–24 hours after the first or second session.
This makes ketamine distinct from traditional antidepressants, which can take weeks to show results.
How Long Does Relief Typically Last?
While some people experience relief after a single infusion, most patients require a series of 6 infusions over 2–3 weeks for sustained benefit.
On average:
Initial relief: within 1–2 infusions
Peak benefit: after 4–6 infusions
Duration of relief: often lasts several weeks to a few months
Some may experience relapse without booster infusions or ongoing care
At Mosaic Infusions & Wellness, we monitor your response closely and adjust your treatment plan for maximum, long-term results.
What About Maintenance (Booster) Infusions?
To extend the benefits of ketamine therapy, many patients return for maintenance or “booster” infusions every 4–8 weeks—or as needed based on symptom return.
Maintenance schedules vary, but studies show that regular boosters can help prevent relapse and keep symptoms in remission.
What Affects How Long Ketamine Relief Lasts?
The duration of ketamine’s effects can vary based on:
Your diagnosis (e.g., depression, PTSD, chronic pain)
Severity and chronicity of symptoms
Lifestyle and wellness habits
Whether you’re receiving integrative care (therapy, nutrition, sleep, etc.)
At Mosaic Infusions & Wellness, we emphasize whole-person care. We work closely with you and your mental health providers to create a sustainable plan for emotional and neurological wellness.
Serving Fairfax, VA and surrounding Northern Virginia and Washington, DC communities.
Patient Experience: What to Expect
“Logan made my ketamine infusion experience one that I will always be grateful for. He was very professional, curious and in depth about my concerns and comfort. As someone who struggled with substance abuse, ketamine therapy truly changed my life. I am sober, experiencing a dramatic change in depression and anxiety levels and now have a clear and positive outlook on almost everything!”– Mosaic Infusions & Wellness Patient, Fairfax VA
Still Have Questions About Ketamine Results?
Whether you're considering your first infusion or wondering how to maintain your progress, we're here to help.
At Mosaic Infusions & Wellness in Fairfax, VA, we provide evidence-based ketamine therapy in a supportive and professional setting. Let’s talk about what’s possible for you.
Schedule a free consultation with our team today.
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