Is Ketamine Safe? What Science Says About IV Ketamine Therapy

Ketamine has gained national attention as a fast-acting treatment for depression, anxiety, and PTSD — especially when traditional therapies fall short. But naturally, many people considering ketamine infusion therapy ask the critical question: Is ketamine safe?

At Mosaic Infusions & Wellness in Fairfax, VA, safety is our top priority. This post walks you through the research-backed safety profile of IV ketamine, so you can make an informed decision with clarity and confidence.

What Is Ketamine?

Originally developed as an anesthetic in the 1960s, ketamine has been used safely in surgical and emergency settings for decades. Over the past 20 years, its mental health benefits — particularly for treatment-resistant depression (TRD) — have been thoroughly studied and recognized.

Is Ketamine FDA-Approved for Mental Health?

The FDA has approved a form of ketamine called esketamine (Spravato) for treatment-resistant depression. While IV ketamine itself is used off-label, it is supported by a strong and growing body of research showing its safety and effectiveness.

Off-label use is common in medicine — and IV ketamine is carefully administered in clinical settings, with standardized protocols, by licensed professionals.

How Safe Is IV Ketamine? What the Research Shows

Multiple studies have confirmed that IV ketamine is generally well-tolerated, especially when administered in a controlled clinical environment like ours.

Key studies:

• Short-term safety: several studies have demonstrated the effectiveness and safety of short term use of ketamine infusions. See here, here, and here

• Long-term use: a systematic review conducted in 2022 showed that longer-term maintenance dosing of ketamine for depression was effective and low side effect.

• Low risk of addiction: new research is being conducted in ketamine's efficacy in the treatment of substance use disorders and addiction.

  
  

Common (and Mild) Side Effects of Ketamine

Most people tolerate ketamine infusions very well. Some possible, temporary side effects include:

• Dissociation or dream-like sensations during the infusion

• Mild nausea or dizziness

• Brief increase in heart rate or blood pressure

• Fatigue following the session

These effects typically wear off within 1–2 hours, and our clinical staff monitors you closely throughout the entire process.

Who Should Avoid Ketamine?

While safe for most, ketamine may not be recommended if you have:

• Uncontrolled high blood pressure

• Certain heart conditions

• History of psychosis or untreated schizophrenia

  
  

At Mosaic Infusions & Wellness, we conduct a comprehensive psychiatric and medical evaluation before initiating treatment, ensuring that ketamine is a safe and appropriate option for you.

What Makes Ketamine Infusion Therapy Safe at Mosaic?

Medical Oversight – All infusions are overseen by licensed professionals trained in psychiatry and anesthetic medicine.

Tailored Dosing – We individualize your ketamine dose based on your health profile and treatment goals.

Calm, Monitored Setting – Your infusion takes place in a quiet, private room with continuous monitoring for comfort and safety.

Ongoing Evaluation – We track your response and adjust your treatment plan with care.

Conclusion: A Promising and Safe Option for Many

When administered in a professional clinical environment like Mosaic Infusions & Wellness, IV ketamine therapy is considered safe, effective, and life-changing for many individuals struggling with treatment-resistant depression and anxiety.

If you're curious about whether ketamine therapy is right for you, we’d be honored to answer your questions.

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